About 40 mutations are associated with the development of schizophrenia even in people without a family history of disease, finding widespread in the latest edition of the journal Nature Genetics.

Genes involved in their appearance even when there is no history and this is because the DNA of an individual is not a replica of the maternal and paternal genetic code, explained scientists at the University of Columbia.

According to experts, during the formation of eggs and sperm are produced genetic mutations.

Researchers at Columbia University (USA) have shown that new genetic mutations that alter the proteins, genetic errors present in patients but not their parents, are associated with more than 50% of cases of schizophrenia are not inherited. The results have been published in the journal Nature Genetics.

From the analysis of 225 individuals, some schizophrenics and healthy ones, found alterations in 40 genes associated with schizophrenia.

The results point the way toward finding more mutations that contribute to the genetics of schizophrenia: a necessary step to understanding how disease develops. "The identification of such damages de novo mutations has radically transformed our understanding of the genetic basis of schizophrenia," said Xu Bin, co-author of the study.

This work also helps explain two mysteries: the persistence of schizophrenia, although people with the disease do not usually spend the mutations to their children and the high global incidence of the disease, despite the large variations in context environment.