Asthma and Chlamydia pneumoniae infection: diagnosis and treatme
Researchers from Finland and the U.S. have shown that this disease may be caused by proteins produced by a common bacterial infection. Meanwhile, other researchers from the U.S. has shown that antibiotics may help relieve symptoms easily the disease.
A potential causative agent is a bacterium called Chlamydia pneumoniae (Cp), which was already known is the common cause of some lung infections. Chlamydia pneumoniae (Cp) has a complex life cycle where it needs to infect other cells to reproduce, so it is classified as an obligatory intracellular pathogen.
A team of scientists from the National Public Health Institute in Oulu, Finland, has proved the theory that asthmatics are more sensitive than others to the presence of a protein produced by Chlamydia pneumoniae. Samples of blood taken from patients with asthma, people with bronchitis and healthy people. Found that it is much more likely to be found in the blood of asthmatics, telltale signs of an immune system response to the protein produced by C. pneumoniae. While the data are interesting, no other research team has been able to replicate these studies. Subsequent research might be revealing.
Asthma and infections
Dr. David L. Hahn is one of U.S. physicians performing treatment with azithromycin to treat asthma. Their arguments are as follows.
"Increasing evidence suggests that half of asthma cases - in children and adults - is associated with a chronic lung infection caused by some atypical microorganisms: Chlamydia pneumoniae (Cp) and Mycoplasma pneumoniae (MP):
* Studies bronchoscopic lavage fluid revealed that over 50% of pediatric asthma is positive for Cp and over 50% of asthma in adults is positive for Cp and / or Mp
* Uncontrolled treatment studies in pediatric patients and adults with asthma showed a marked improvement (or even complete remission) associated with microbiological eradication
* An unpublished randomized clinical trial in adults found that azithromycin was associated with improvement in symptoms of asthma and found that 50% of patients were given clinically significant decreases in rescue medication and improvement in asthma or in their quality of life
Current evidence is insufficient to justify recommendations for antibiotic treatment. Based on the information presented above, patients with poorly controlled asthma who are not responding to conventional anti-inflammatory treatments may seek a solution on antibiotics. In addition to patients with severe asthma, patients recently diagnosed with asthma may choose to treat empirically with antibiotics before accepting the chronic steroid treatment. "
Dr. Hahn recommended not to select patients who may be given antibiotic treatment based on, for example, serological tests for antibodies to Chlamydia as:
* It is true that the presence of these antibodies predict a good response to treatment.
* Other microorganisms (eg, Mycoplasma, or other unidentified) may also be involved.
* The mechanisms responsible for the response to antibiotic treatment are unknown.
Dr. Hahn recommended regimen of treatment with azithromycin, which you can check here.
Dr. Hahn himself, along with treatment gives patients the following information:
"1 .- This treatment is empirical and is not approved by the FDA.
2 .- You must continue with their usual rescue medication for asthma and control drugs, for the moment.
3 .- Do not expect any response to this treatment for several weeks or even months. "