The results tested in mice, show the therapeutic potential of PARP inhibitors, a key molecule in the repair of DNA damage induced on. The research has been published in the journal PLoS Genetics.
"Metastasis is the spread of invasive tumor cells from where it originates to other parts of the body, and causes the vast majority of mortality associated with solid tumors," said CSIC researcher Javier Oliver, the Institute Parasitology and Biomedicine López Neyra.
This work describes the PARP enzyme capacity to regulate the expression of factors such as vimentin and VE-cadherin, the dynamic key proteins in vascular cells located around the tumor and malignant transformation processes, such as vascular and mimicry acquiring invasive properties.
The investigation also involved researchers from the Research Institute of Biopathology and Regenerative Medicine, University of Granada, the Center for Genomics and Oncological Research and Pompeu Fabra University.
Mª Isabel Rodríguez*, Andreína Peralta-Leal, Francisco O’Valle, José Manuel Rodriguez-Vargas, Ariannys Gonzalez-Flores, Jara Majuelos-Melguizo, Laura López, Santiago Serrano, Antonio García de Herreros, Juan Carlos Rodríguez-Manzaneque, Rubén Fernández, Raimundo G. del Moral, Mariano Ruiz de Almodóvar, F. Javier Oliver. PARP-1 regulates metastatic melanoma through modulation of vimentininduced malignant transformation. PLOS Genetics. DOI: 10.1371/journal.pgen.1003531